I work with both audio and MIDI in 48-track software with nearly endless sampling and synthesizing capabilities, though I'm partial to the natural sound of real instruments. But to get synths to sound more 'human,'  it helps to use a MIDI drumset, MIDI guitar, and breath controller.

Instruments: drums & percussion, guitars, bass-guitars, keyboards/synths, mandolin, violin, harmonica, & fine found objects. 

Written, Performed & Recorded by Imre de Jonge except final selection from the TV show "Tek War" © Warner Bros. Television

If you're a musician who works with MIDI, consider having your midi drums tracks done by a professional drummer on a full midi set, or you can choose real acoustic drums delivered as a .wav file for insertion into your sequences.

Recording label and artist representation

Also the home of I. de Jonge Guitars & Basses